BENZOTHIAZOLE MEROTERPENOID COMPOUND AND DERIVATIVE THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF

A benzothiazole meroterpenoid compound derived from deep sea fungi and a derivative thereof, and a preparation method therefor and the use thereof in the preparation of an anti-tumor drug are provided. The benzothiazole meroterpenoid compound is a compound as represented by formulas I to III or a sa...

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Bibliographische Detailangaben
Hauptverfasser:	HE, Zhihui, YAN, Qingxiang, XIE, Chunlan, ZOU, Zhenbiao, YANG, Xianwen
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A benzothiazole meroterpenoid compound derived from deep sea fungi and a derivative thereof, and a preparation method therefor and the use thereof in the preparation of an anti-tumor drug are provided. The benzothiazole meroterpenoid compound is a compound as represented by formulas I to III or a salt thereof. The compound is isolated from a fermentation product of deep-sea-derived Penicillium allii-sativi and inhibits the transcriptional activity of an anti-tumor target RXRalpha by means of binding thereto so as to achieve a remarkable anti-tumor effect. The compound can be used for preparing, researching and developing anti-cancer drugs, and has good application prospects.