COMPOUND INCLUDING A HETEROATOM AND NUCLEOBASE

The disclosure is directed to a compound of formula III:wherein: X is a heteroatom; Base is a nucleobase; R1 and R2 are each independently selected from the group consisting of H, CF3, CN, a C1-C12 straight chain or branched alkyl, a C2-C12 straight chain or branched alkenyl or polyenyl, a C2-C12 st...

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Bibliographische Detailangaben
Hauptverfasser: Honeybun, David, Bean, Isaac, Kemble, Henry, West, Lawrence C, Hansen, William A, Rothberg, Jonathan M, Zahorian, Jaime Scott, Camara, Jose, Schneider, Lindsay
Format: Patent
Sprache:eng
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Zusammenfassung:The disclosure is directed to a compound of formula III:wherein: X is a heteroatom; Base is a nucleobase; R1 and R2 are each independently selected from the group consisting of H, CF3, CN, a C1-C12 straight chain or branched alkyl, a C2-C12 straight chain or branched alkenyl or polyenyl, a C2-C12 straight chain or branched alkynyl or polyalkynyl, a C1-C12 ether, and an aromatic group (e.g., a phenyl, a naphthyl, a pyridine), with the proviso that at least one of R1 and R2 is CF3, CN, a C1-C12 straight chain or branched alkyl, a C2-C12 straight chain or branched alkenyl or polyenyl, a C2-C12 straight chain or branched alkynyl or polyalkynyl, a C1-C12 ether, or an aromatic group (e.g., a phenyl, a naphthyl, a pyridine); R3 is NO2; R4 is H; R5 comprises a C1-C12 alkyne, an amide, and/or an amine; R6 is OMe or S-C6H6; and R7 is H or NO2.