CRYSTAL FORM OF COMPOUND AND FUMARIC ACID, PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING CORONAVIRUS-INDUCED DISEASES

The present disclosure provides a crystal form comprising a compound of Formula (I) and fumaric acid, wherein the crystal form satisfies at least one of the following conditions: (1) a particle size D90 of the active pharmaceutical ingredient ranges from about 5 μm to about 60 μm; and (2) a particle...

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Bibliographische Detailangaben
Hauptverfasser:	YANG, Jiannan, LI, Chao, WANG, Bin, QU, Lei, ZHAO, Taotao, WEI, Weiye, WU, Xiaotao, WANG, Hao
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present disclosure provides a crystal form comprising a compound of Formula (I) and fumaric acid, wherein the crystal form satisfies at least one of the following conditions: (1) a particle size D90 of the active pharmaceutical ingredient ranges from about 5 μm to about 60 μm; and (2) a particle size D50 of the active pharmaceutical ingredient does not exceed about 30 μm; a pharmaceutical composition containing the crystal form, and a method for treating coronavirus-induced diseases by using the crystal form. The crystal form of the present disclosure enables the pharmaceutical composition containing the crystal form to have advantages such as a higher dissolution rate, a higher dissolution, and the like.