2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH

2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH

The present invention provides triazolone compounds of general formula (I):in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds an...

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Bibliographische Detailangaben
Hauptverfasser: GÜNTHER, Judith, MÜLLER, Thomas, FERRARA, Steven James, KRÖBER, Michael, NISING, Carl Friedrich, NGUYEN, Duy, STELLFELD, Timo, CHRISTIAN, Sven, JANZER, Andreas, SYKES, David B, ZHOU, Han Jie, ZHAO, Changjia, GRADL, Stefan Nikolaus, SHEIKH, Sherif El, NIEHUES, Michael, ZIMMERMANN, Katja, SCHÄFER, Martina, MERZ, Claudia, EIS, Knut, LIU, Kery
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides triazolone compounds of general formula (I):in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.