MODIFIED FC REGIONS

The present invention relates to the field of modified constant domains of canine or feline antibodies having altered immune-effector functions and their use. More specifically, the application relates to modified Fc fragments having significantly reduced FcγRI and C1q binding.

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Bibliographische Detailangaben
Hauptverfasser:	BRAND, Verena, SCHNEIDER, Christina, WALDHUBER, Markus, STERNER, Andrea
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention relates to the field of modified constant domains of canine or feline antibodies having altered immune-effector functions and their use. More specifically, the application relates to modified Fc fragments having significantly reduced FcγRI and C1q binding.