COMPOUNDS AND METHODS FOR TREATING TIGHT JUNCTION PERMEABILITY

COMPOUNDS AND METHODS FOR TREATING TIGHT JUNCTION PERMEABILITY

The present invention provides Larazotide derivative compositions that resist protease degradation, and in various embodiments, do not demonstrate an inverse dose response, and/or can be delivered at higher doses without loss of potency or efficacy, thereby allowing improved therapy more desirable d...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LAUMAS, Sandeep, RADHAKRISHNAN, Balasingham, MADAN, Jay P, PRIOR, Christopher
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides Larazotide derivative compositions that resist protease degradation, and in various embodiments, do not demonstrate an inverse dose response, and/or can be delivered at higher doses without loss of potency or efficacy, thereby allowing improved therapy more desirable dosing schedules.