PREPARATION AND USES OF OBETICHOLIC ACID

The present invention relates to obeticholic acid:or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing H...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Waenerlund Poulsen, Heidi, Jolibois, Emilie, Rewolinski, Melissa, Dubas-Fisher, Fiona, Eberlin, Alex, Gross, Ralf, STEINER, André, Sharp, Emma
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES STEROIDS
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Beschreibung
Zusammenfassung:	The present invention relates to obeticholic acid:or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid.