COMPOSITIONS OF AJULEMIC ACID AND USES THEREOF

COMPOSITIONS OF AJULEMIC ACID AND USES THEREOF

The invention relates to crystalline forms of (6aR,10aR)-1-Hydroxy-6, 6-dimethyl-3-(2-methyl-2-octanyl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene-9-carboxylic acid (ajulemic acid), including pharmaceutical compositions comprising a crystalline form of ajulemic acid and methods of making a crystalli...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEIGH, Clifton David, BOOTH, David Richard, GUO, Feng, TADAYON, Abdolsamad, DISCORDIA, Robert Paul, XU, Tingting, DENG, Chaoyi, REECE, Hayley Ann, MOSHOS, Kristos Adrian, ZHANG, Hang
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to crystalline forms of (6aR,10aR)-1-Hydroxy-6, 6-dimethyl-3-(2-methyl-2-octanyl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene-9-carboxylic acid (ajulemic acid), including pharmaceutical compositions comprising a crystalline form of ajulemic acid and methods of making a crystalline form of ajulemic acid. The invention also relates to the use of pharmaceutical compositions comprising a crystalline form of ajulemic acid for the treatment of disease, including inflammatory diseases and fibrotic diseases.