POSTERIOR SEGMENT DRUG DELIVERY

A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in th...

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Bibliographische Detailangaben
Hauptverfasser:	Alster, Yair, Chamow, Steven M, George, Robert, Sutton, Douglas, Barrett, Michael, de Juan, Jr., Eugene, Farinas, Kathleen C, Campbell, Randolph E, Macfarlane, K. Angela, Gifford, III, Hanson S, Reich, Cary J
Format:	Patent
Sprache:	eng
Schlagworte:	BANDAGES, DRESSINGS OR ABSORBENT PADS DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROSTHESES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.TABLE 1ATherapeutic Agent ListGeneric NameBrands (Companies)CategoryIndicationMolecular Weight2-Methoxyestradiol analogs(Paloma Pharmaceuticals)Angiogenesis inhibitorsAMD3-aminothalidomide13-cis retinoic acidAccutane™ (Roche Pharmaceuticals)A0003(Aqumen BioPharmaceuticals)A0003AMDA5b1 integrin inhibitor(Jerini Ophthalmic); (Ophthotech)Inhibitors of a5b1 integrinAMDAbarelixPlenaxis™(Praecis Pharmaceuticals)Anti-Testosterone Agents; Antineoplastic AgentsFor palliative treatment of advanced prostate cancer.37731AbataceptOrencia™(Bristol-Myers Squibb)Antirheumatic AgentsFor the second line reduction of the signs and symptoms of moderate-to-severe active rheumatoid arthritis, inducing inducing major clinical response, slowing the progression of structural damage, and improving physical function in adult patients who have37697AbciximabReoPro™; ReoPro™ (Centocor)Anticoagulants; Antiplatelet AgentsFor treatment of myocardial infarction, adjunct to percutaneous 2oronary intervention, unstable angina42632ABT-578(Abbott Laboratories)Limus Immunophilin Binding CompoundsAcetonideAdalimumabHumira™ (Abbott Laboratories)Antirheumatic Agents; Immunomodulatory AgentsFor treatment of rheumatoid arthritis25645AldesleukinProleukin™; Proleukin™ (Chiron Corp)Antineoplastic AgentsFor treatment of adults with metastatic renal cell carcinoma61118AlefaceptAmevive™Immunomodulatory Agents; Immunosuppressive AgentsFor treatment of moderate to severe chronic plaque psoriasis42632AlemtuzumabCampath™; Campath™ (ILEX Pharmaceuticals LP); MabCampath™Antineoplastic AgentsFor treatment of B-cell chronic lymphocytic leukemia6614Alpha-1-proteinase inhibitorAralast™ (Baxter); Prolastin™ (Talecris Biotherapeutics C formerly Bayer)Enzyme Replacement AgentsFor treatment of panacinar emphysema28518AlteplaseActivase™ (Genentech Inc)Thromboly