THE ANTIVIRAL DRUG TILORONE IS A POTENT AND SELECTIVE INHIBITOR OF ACETYLCHOLINESTERASE

THE ANTIVIRAL DRUG TILORONE IS A POTENT AND SELECTIVE INHIBITOR OF ACETYLCHOLINESTERASE

The identification of new acetylcholinesterase (AChE) inhibitors is described. For example, tilorone was newly identified as an AChE inhibitor by use of a machine learning model followed by in vitro screening. The new AChE inhibitors can selectively inhibit AChE compared to butyrylcholinesterase (Bu...

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Bibliographische Detailangaben
Hauptverfasser: Ekins, Sean, Puhl Rubio, Ana C, Vignaux, Patricia A
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The identification of new acetylcholinesterase (AChE) inhibitors is described. For example, tilorone was newly identified as an AChE inhibitor by use of a machine learning model followed by in vitro screening. The new AChE inhibitors can selectively inhibit AChE compared to butyrylcholinesterase (BuChE). Methods of inhibiting AChE and of treating or preventing diseases, disorders, and conditions treatable or preventable by AChE inhibition are also described. For example, methods of treating and/or preventing certain dermatological conditions and organophosphorous or nerve agent poisoning are described.