CLOSED LINEAR DNA WITH MODIFIED NUCLEOTIDES

The present invention provides closed linear DNA (clDNA) consisting of a stem region comprising a double stranded DNA sequence of interest covalently closed at both ends by hairpin loops, the clDNA comprising at least two modified nucleotides. The invention also provides the clDNA for use in therapy...

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Bibliographische Detailangaben
1. Verfasser:	OYARZABAL SANTAMARINA, Julen
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides closed linear DNA (clDNA) consisting of a stem region comprising a double stranded DNA sequence of interest covalently closed at both ends by hairpin loops, the clDNA comprising at least two modified nucleotides. The invention also provides the clDNA for use in therapy, in particular, gene therapy, as well as pharmaceutical compositions comprising the clDNA and a method for the production of the clDNA.