MULTISPECIFIC ANTIBODIES THAT BIND BOTH MAIT AND TUMOR CELLS

MULTISPECIFIC ANTIBODIES THAT BIND BOTH MAIT AND TUMOR CELLS

The invention provides a multispecific molecule capable of simultaneous binding to a Mucosal Associated Invariant T (MAIT) cell and a tumor cell, which multispecific molecule comprises at least one domain that specifically binds a Vα7.2 T cell receptor (TCR) and at least one domain that specifically...

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Hauptverfasser: SAITAKIS, MICHAEL, AMIGORENA, SEBASTIAN, LANTZ, OLIVIER, GUILLOT-DELOST, MAUDE, FAROUDI, MUSTAPHA, GERARD, PIERRE-EMMANUEL, ZHUKOVSKY, EUGENE
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Sprache:eng
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator SAITAKIS, MICHAEL
AMIGORENA, SEBASTIAN
LANTZ, OLIVIER
GUILLOT-DELOST, MAUDE
FAROUDI, MUSTAPHA
GERARD, PIERRE-EMMANUEL
ZHUKOVSKY, EUGENE
description The invention provides a multispecific molecule capable of simultaneous binding to a Mucosal Associated Invariant T (MAIT) cell and a tumor cell, which multispecific molecule comprises at least one domain that specifically binds a Vα7.2 T cell receptor (TCR) and at least one domain that specifically binds a tumor associated antigen (TAA).
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title MULTISPECIFIC ANTIBODIES THAT BIND BOTH MAIT AND TUMOR CELLS
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