MULTISPECIFIC ANTIBODIES THAT BIND BOTH MAIT AND TUMOR CELLS

MULTISPECIFIC ANTIBODIES THAT BIND BOTH MAIT AND TUMOR CELLS

The invention provides a multispecific molecule capable of simultaneous binding to a Mucosal Associated Invariant T (MAIT) cell and a tumor cell, which multispecific molecule comprises at least one domain that specifically binds a Vα7.2 T cell receptor (TCR) and at least one domain that specifically...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SAITAKIS, MICHAEL, AMIGORENA, SEBASTIAN, LANTZ, OLIVIER, GUILLOT-DELOST, MAUDE, FAROUDI, MUSTAPHA, GERARD, PIERRE-EMMANUEL, ZHUKOVSKY, EUGENE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides a multispecific molecule capable of simultaneous binding to a Mucosal Associated Invariant T (MAIT) cell and a tumor cell, which multispecific molecule comprises at least one domain that specifically binds a Vα7.2 T cell receptor (TCR) and at least one domain that specifically binds a tumor associated antigen (TAA).