CYTOKINE-BASED MULTI-EPITOPE PROTEIN FOR BINDING TO CCR7-POSITIVE CELLS

A cytokine-based multi-epitope protein for binding to CC-chemokine receptor type 7 (CCR7)-positive cells, including immunomodulatory molecules. The immunomodulatory molecules include a truncated granulocyte-macrophage colony-stimulating factor (GM-CSF), truncated chemokines, a truncated interleukin...

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Bibliographische Detailangaben
Hauptverfasser: Beihaghi, Maria, Marashi, Hasan
Format: Patent
Sprache:eng
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Zusammenfassung:A cytokine-based multi-epitope protein for binding to CC-chemokine receptor type 7 (CCR7)-positive cells, including immunomodulatory molecules. The immunomodulatory molecules include a truncated granulocyte-macrophage colony-stimulating factor (GM-CSF), truncated chemokines, a truncated interleukin 1 beta (IL-1β), and a chemokine secretory signal peptide. The truncated chemokines include a truncated CC-chemokine ligand-19 (CCL19) and a truncated CC-chemokine ligand-21 (CCL21). Each of the truncated chemokines includes a respective DCCL motif, a respective putative receptor binding cleft, and a respective putative glycosaminoglycan binding site.