Process for the preparation of oligonucleotides using modified oxidation protocol

Process for the preparation of oligonucleotides using modified oxidation protocol

The invention relates to a process for the production of a mixed P═O/P═S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the schemeapplying a novel oxidation protocol and t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FETTES, Alec, JAITZ, Leonhard, GEISER, Achim
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:The invention relates to a process for the production of a mixed P═O/P═S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the schemeapplying a novel oxidation protocol and to new oxidation solutions.