EGFR ANTIGEN BINDING FRAGMENTS AND COMPOSITIONS COMPRISING SAME

EGFR ANTIGEN BINDING FRAGMENTS AND COMPOSITIONS COMPRISING SAME

The present disclosure related to antigen-binding units that specifically bind to EGFR or epitopes thereof. Some embodiments include bispecific anti-EGFR/anti-CD3 constructs with improved expression and/or stability. Related methods are also disclosed.

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Bibliographische Detailangaben
Hauptverfasser: MACCANN, Darragh, FRENZEL, André, SCHELLENBERGER, Volker, KUHN, Phillipp, MCCLORY, James
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure related to antigen-binding units that specifically bind to EGFR or epitopes thereof. Some embodiments include bispecific anti-EGFR/anti-CD3 constructs with improved expression and/or stability. Related methods are also disclosed.