System and Method for identifying potential false positive and blind spot locations in catheter-based multimodal images

A system, method, and computer-readable media configured to process image data for detecting blind spot locations in multimodality images acquired by an imaging catheter. The method comprises: acquiring a multimodality image of a blood vessel, the multimodality image includes first image data co-registered with second image data collected simultaneously by scanning an inner wall of the blood vessel with light of two or more wavelengths transmitted through the catheter; analyzing the first image data to identify a characteristic feature of the blood vessel; detecting, based on the characteristic feature of the blood vessel, a potential blind spot location of the second image data in the multimodality image; and displaying on a display device the multimodality image with a marker showing the potential blind spot location of the second image data in relation to the first image data.