NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF

NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF

Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein ---, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kargbo, Robert Borbo, Robichaud, Albert Jean, Herr, Robert Jason, Martinez Botella, Gabriel, Harrison, Boyd L, Salituro, Francesco G
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
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Beschreibung
Zusammenfassung:Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein ---, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.