Formulation, Dosage Regimen, and Manufacturing Process for Heterodimeric FC-Fused Proteins

The present invention relates to pharmaceutical formulations for heterodimeric Fc-fused proteins which are advantageous for achieving higher titers of the proteins during production, higher stability during storage, and improved efficacy when used as a therapeutic. Also provided are dosage regimens...

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Bibliographische Detailangaben
Hauptverfasser:	Derose, Mark, Grinberg, Asya, Bigelow, Mitchell, Naill, Michael C, Shifrin, Michael, Wagtmann, Nicolai, Braun, Alexandra, Gutierrez, Eva, Cuillerot, Jean-Marie, Morgan, Christopher Ryan, Cheung, Ann F, O'Neil, Steven, Kirby, Patrick
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical formulations for heterodimeric Fc-fused proteins which are advantageous for achieving higher titers of the proteins during production, higher stability during storage, and improved efficacy when used as a therapeutic. Also provided are dosage regimens for such heterodimeric Fc-fused proteins and pharmaceutical formulations for use in treating cancer, such as locally advanced or metastatic solid tumor.