HUMANIZED ANTIBODY SPECIFIC TO BACILLUS ANTHRACIS PROTECTIVE ANTIGEN AND PREPARATION METHOD THEREOF

The present invention relates to a humanized antibody specific to a Bacillus anthracis protective antigen and a preparation method thereof. An antibody library is created by obtaining a Bacillus anthracis protective antigen antibody of a monkey from immune cells obtained by immunizing a Bacillus ant...

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Bibliographische Detailangaben
Hauptverfasser:	Hur, Gyeung-Haeng, Joe, Hae-Eun, Song, Dong-Hyun, Kim, Na-Young, Kim, Chang-Hwan, Shin, Young-Kee, Yu, Chi-Ho, Jeong, Seong-Tae, Choi, Jun-Young, Jeong, Hyun-Ho, Jun, Seung-Chul
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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Beschreibung
Zusammenfassung:	The present invention relates to a humanized antibody specific to a Bacillus anthracis protective antigen and a preparation method thereof. An antibody library is created by obtaining a Bacillus anthracis protective antigen antibody of a monkey from immune cells obtained by immunizing a Bacillus anthracis protective antigen, an antibody specific to the Bacillus anthracis protective antigen is selected from the created antibody library, and, on the basis of the antibody, a humanized antibody specific to the Bacillus anthracis protective antigen is finally selected by creating a humanized antibody library against a Bacillus anthracis protective antigen. The selected humanized antibody specific to the Bacillus anthracis protective antigen exhibits very high Bacillus anthracis protective antigen affinity and toxin neutralization capacity and has a neutralizing effect in the body before and after exposure to Bacillus anthracis, and thus can be used as a therapeutic composition for treating or preventing an anthrax.