Blood-Brain Barrier Penetrating Aptamer and Use Thereof

The present invention relates to an aptamer penetrating the blood-brain barrier (BBB) to enable receptor-mediated transcytosis and a use thereof.The aptamer of the present invention selectively targets transferring receptor proteins only, rapidly passes through BBB by means of receptor-mediated tran...

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Bibliographische Detailangaben
Hauptverfasser:	Lim, So Ryong, Kim, Youndong, Kim, Soyeon, Shin, Euisu, Kang, Naye, Lee, Da Som, Han, Dongil
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to an aptamer penetrating the blood-brain barrier (BBB) to enable receptor-mediated transcytosis and a use thereof.The aptamer of the present invention selectively targets transferring receptor proteins only, rapidly passes through BBB by means of receptor-mediated transcytosis, can effectively transport and deliver various therapeutic agents such as proteins, antibodies, nucleic acids, and low-molecular weight compounds through simple chemical bonds, exhibits interspecific cross-reactivity in transferring receptors, and is easily chemically modified, and thus is applicable as a drug carrier for nervous system diseases, especially brain and central nervous systems.