CHIRAL PHOSPHORAMIDITE AUXILIARIES AND METHODS OF THEIR USE
Disclosed are P-stereogenic groups that may be used in the synthesis of compounds including stereochemically enriched P-stereogenic phosphorothioates. P-stereogenic groups may be provided in nucleoside phosphoramidites including a sugar bonded to a nucleobase and to a stereochemically enriched phosp...
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| creator | LIU, Dingguo ELTEPU, Laxman SAKAMURI, Sukumar BRADSHAW, Curt W |
| description | Disclosed are P-stereogenic groups that may be used in the synthesis of compounds including stereochemically enriched P-stereogenic phosphorothioates. P-stereogenic groups may be provided in nucleoside phosphoramidites including a sugar bonded to a nucleobase and to a stereochemically enriched phosphoramidite as well as methods of their use and methods of making them. |
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| subjects | CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS |
| title | CHIRAL PHOSPHORAMIDITE AUXILIARIES AND METHODS OF THEIR USE |
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