CHIRAL PHOSPHORAMIDITE AUXILIARIES AND METHODS OF THEIR USE

CHIRAL PHOSPHORAMIDITE AUXILIARIES AND METHODS OF THEIR USE

Disclosed are P-stereogenic groups that may be used in the synthesis of compounds including stereochemically enriched P-stereogenic phosphorothioates. P-stereogenic groups may be provided in nucleoside phosphoramidites including a sugar bonded to a nucleobase and to a stereochemically enriched phosp...

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Bibliographische Detailangaben
Hauptverfasser: LIU, Dingguo, ELTEPU, Laxman, SAKAMURI, Sukumar, BRADSHAW, Curt W
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:Disclosed are P-stereogenic groups that may be used in the synthesis of compounds including stereochemically enriched P-stereogenic phosphorothioates. P-stereogenic groups may be provided in nucleoside phosphoramidites including a sugar bonded to a nucleobase and to a stereochemically enriched phosphoramidite as well as methods of their use and methods of making them.