PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS

PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS

Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula A, as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof:wherein either R1 or R2 is independently Cl, F, -CF3, or -CH3, and the oth...

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Bibliographische Detailangaben
Hauptverfasser: HAWK, Mai Khanh Nguyen, KJELL, Douglas Patton, ARGUELLES DELGADO, Alonso Jose, LU, Yu, CZESKIS, Boris Arnoldovich, REMICK, David Michael, MAGNUS, Nicholas Andrew
Format: Patent
Sprache:eng
Schlagworte:
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Beschreibung
Zusammenfassung:Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula A, as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof:wherein either R1 or R2 is independently Cl, F, -CF3, or -CH3, and the other is H; and R7 is H or PG.