Deuterated Pyridopyrimidinones And Their Use As Highly Selective Cyclin-Dependent Kinase 2 Inhibitors

Deuterated Pyridopyrimidinones And Their Use As Highly Selective Cyclin-Dependent Kinase 2 Inhibitors

The present invention relates to deuterated pyridopyrimidinone compounds and pharmaceutically acceptable salts thereof with inhibitory activity at cyclin dependent kinase 2 (CDK2) kinase, pharmaceutical composition comprising such compounds and methods of using such compounds for treating diseases a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Shuai, Bian, Wangdong, Wu, Jiaquan, Gao, Minqi, Lu, Zhenghua, Gui, Wenjun, Fan, Feng
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to deuterated pyridopyrimidinone compounds and pharmaceutically acceptable salts thereof with inhibitory activity at cyclin dependent kinase 2 (CDK2) kinase, pharmaceutical composition comprising such compounds and methods of using such compounds for treating diseases associated with cell-cycle dysregulation.