CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS

CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS

This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and --- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of usi...

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Hauptverfasser: LI, Wenjun, GUO, Zhixiang, HUANG, Yuanyuan, ZHAO, Robert, ZHENG, Wei, YANG, Qingliang, CAI, Xiang, HUANG, Shangma, CHEN, Xiaoxiao, WANG, Xiaoxu, YE, Hangbo, CHEN, Diancheng, ZHANG, Lingli, ZHANG, Xiuzhen, LI, Yanhua, ZHENG, Jun, ZHAO, Gengxiang, CHEN, Miaomiao, JIA, Junxiang, JIANG, Xinyan, GUO, Huihui, XU, Yifang, DU, Yong, LIN, Chen, YE, Riping, KONG, Xiangfei, ZHENG, Yunxia, BAI, Lu
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and --- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.