SYNTHESIS METHOD AND APPLICATION OF METFORMIN HYDROCHLORIDE

The present invention belongs to the field of pharmaceutical synthesis, disclosing a synthetic process and application of metformin hydrochloride, which is to take dicyandiamine and dimethylamine, after dissolving in lower alcohol, adding sodium alkoxide, mixing evenly and gradually raising the temp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	YU, Guoxin, ZHU, Yadong, XU, Danqing, GENG, Liang
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention belongs to the field of pharmaceutical synthesis, disclosing a synthetic process and application of metformin hydrochloride, which is to take dicyandiamine and dimethylamine, after dissolving in lower alcohol, adding sodium alkoxide, mixing evenly and gradually raising the temperature for condensation reaction, after the reaction ends, adding hydrochloric acid to adjust the pH to acidic, that is, metformin hydrochloride as described. The synthetic process of metformin hydrochloride provided in this invention, reduces the energy consumption during the reaction, reduces the production cost, and reduces the difficulty of product purification. The present invention is applicable to the synthesis of metformin hydrochloride, the as synthesized metformin hydrochloride is used to prepare metformin hydrochloride sustained release tablets.