FUSED HETEROARYL HYDROXAMATES AS STING AGONISTS

FUSED HETEROARYL HYDROXAMATES AS STING AGONISTS

The invention provides novel substituted heterocyclic compounds represented by the Formulas I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as agonists of Stimulator of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEE, Jungwoo, KIM, Sunjoo, YOON, Cheolhwan, SEO, Jeongbeob, HAN, Cheolkyu, JEON, Sunhwa, LEE, Jinwoo, JEON, Seeun, KANG, Hongjun, YANG, Inho, KANG, Byungnam, SHIN, Youngdo
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention provides novel substituted heterocyclic compounds represented by the Formulas I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as agonists of Stimulator of Interferon Genes (STING) and are useful in the treatment of cancers and certain infectious diseases.