TREM COMPOSITIONS AND METHODS RELATING THERETO

The disclosure relates generally to methods of modulating a production parameter of an RNA corresponding to, or polypeptide encoded by, a nucleic acid sequence comprising an endogenous ORF having a premature termination codon, comprising administering a tRNA-based effector molecule having a non-natu...

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Bibliographische Detailangaben
Hauptverfasser: Butler, David Charles Donnell, Anastassiadis, Theonie, Kubica, Neil, Li, Qingyi
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The disclosure relates generally to methods of modulating a production parameter of an RNA corresponding to, or polypeptide encoded by, a nucleic acid sequence comprising an endogenous ORF having a premature termination codon, comprising administering a tRNA-based effector molecule having a non-naturally occurring modification.