PYRIDINYLACETAMIDE DERIVATIVES AS SODIUM CHANNEL ACTIVATORS

PYRIDINYLACETAMIDE DERIVATIVES AS SODIUM CHANNEL ACTIVATORS

The present disclosure is directed to compounds of formula (I):wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Wei, Rajamani, Ramkumar, Johnstone, Shawn, Lofstrand, Verner Alexander, Sun, Shaoyi, Clark, Michael, Burford, Kristen Nicole, Charifson, Paul, Munuganti, Ravi, Wesolowski, Steve, Sabbatani, Juliette, Kim, Jung Yun, Scholtes, Jan Felix, Clement, Helen
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present disclosure is directed to compounds of formula (I):wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.