Formulations of Human Parathyroid Hormone (PTH) and Methods for Producing Same

Stable liquid pharmaceutical formulations comprising human parathyroid hormone are provided herein. In various embodiments, the stable liquid pharmaceutical formulations comprise human parathyroid hormone (huPTH); a buffering agent to maintain the pH range of the solution from 3 to 6; one or more st...

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Hauptverfasser: Guo, Xiang, Li (deceased), Tiansheng, Yang, Chun, Li, Xiaowen, Wang, Huan, Shi, Lei, Zhang, Linhong
Format: Patent
Sprache:eng
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Zusammenfassung:Stable liquid pharmaceutical formulations comprising human parathyroid hormone are provided herein. In various embodiments, the stable liquid pharmaceutical formulations comprise human parathyroid hormone (huPTH); a buffering agent to maintain the pH range of the solution from 3 to 6; one or more stabilizing agents selected from the group consisting of sugars, salts, surfactants, proteins, chaotropic agents, lipids, and amino acids; a tonicity modifier; water; and optionally a parenterally acceptable preservative; and wherein said solution is sterile and ready for parenteral administration to a human patient.