PRUSSIAN BLUE NANOPARTICLES FUNCTIONALIZATION WITH LATENCY REVERSING AGENTS AND BROADLY NEUTRALIZING ANTIBODIES, AND APPLICATIONS THEREOF

PRUSSIAN BLUE NANOPARTICLES FUNCTIONALIZATION WITH LATENCY REVERSING AGENTS AND BROADLY NEUTRALIZING ANTIBODIES, AND APPLICATIONS THEREOF

Embodiments of the instant disclosure relate to novel compositions and methods for the treatment of retroviruses (e.g., HIV) and the reduction and/or eradication of latent HIV reservoirs. Compositions herein may include biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prus...

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Bibliographische Detailangaben
Hauptverfasser: SARABIA, INDRA, STOVER, CARISSA, RAMANUJAM, ANVITHA SHRI, FERNANDES, ROHAN, BOSQUE, ALBERTO, BALAKRISHNAN, PREETHI BALA
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Embodiments of the instant disclosure relate to novel compositions and methods for the treatment of retroviruses (e.g., HIV) and the reduction and/or eradication of latent HIV reservoirs. Compositions herein may include biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with at least one biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.