ARRAYS AND METHODS FOR IDENTIFYING BINDING SITES ON A PROTEIN

A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is usef...

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Hauptverfasser:	LIGHTWOOD, Daniel John, SPILIOTOPOULOS, Anastasios, KELM, Sebastian, Wright, Michael John, MCMILLAN, David James, LIU, Xiaofeng
Format:	Patent
Sprache:	eng
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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creator	LIGHTWOOD, Daniel John SPILIOTOPOULOS, Anastasios KELM, Sebastian Wright, Michael John MCMILLAN, David James LIU, Xiaofeng
description	A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is useful for determining binding sites (epitopes) of antibodies, ligands and related molecules.
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subjects	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
title	ARRAYS AND METHODS FOR IDENTIFYING BINDING SITES ON A PROTEIN
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