ARRAYS AND METHODS FOR IDENTIFYING BINDING SITES ON A PROTEIN

ARRAYS AND METHODS FOR IDENTIFYING BINDING SITES ON A PROTEIN

A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is usef...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LIGHTWOOD, Daniel John, SPILIOTOPOULOS, Anastasios, KELM, Sebastian, Wright, Michael John, MCMILLAN, David James, LIU, Xiaofeng
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is useful for determining binding sites (epitopes) of antibodies, ligands and related molecules.