METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS

This disclosure provides methods of making immune effector cells (for example, T cells, NK cells) that comprise (i) a nucleic acid molecule that encodes a controllable chimeric antigen receptor (CCAR) or (ii) a nucleic acid molecule that encodes a CAR and a regulatory molecule, and compositions gene...

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Hauptverfasser:	BROGDON, Jennifer, Greene, Michael R, STEIN, Andrew Marc, KODRASI, Olja, TREANOR, Louise, LIM, Hyungwook, PRATICO, Elizabeth Dorothy, PRICE, Andrew, DRANOFF, Glenn, GUIMARAES, Carla Patricia Pinto, ZHU, Xu, SHARMA, Sujata, HACK, Anniesha, HILD, Marc Horst Peter, ENGELS, Boris, CARBONNEAU, Seth, SOHONI, Akash, BONDANZA, Attilio
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This disclosure provides methods of making immune effector cells (for example, T cells, NK cells) that comprise (i) a nucleic acid molecule that encodes a controllable chimeric antigen receptor (CCAR) or (ii) a nucleic acid molecule that encodes a CAR and a regulatory molecule, and compositions generated by such methods.