Organotypic Brain Slice Culture Model of Human Neuroinflammatory Environment Associated with Neurodegeneration

Described herein are methods, compositions, and assay systems that provide a useful ex vivo model for neurodegenerative disorders, by providing a whole brain organotypic slice culture model maintains viability of mature CNS cells from adult animals. In addition, the whole brain slice cultures descri...

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Hauptverfasser:	Larson, Kelley C, Tate, Barbara A, Martens, Lauren H
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Zusammenfassung:	Described herein are methods, compositions, and assay systems that provide a useful ex vivo model for neurodegenerative disorders, by providing a whole brain organotypic slice culture model maintains viability of mature CNS cells from adult animals. In addition, the whole brain slice cultures described herein exhibit hallmarks of chronic neuroinflammation, where hallmarks are consistent across age-related neurodegenerative disorders. Also provided herein is a cultured whole brain slice which exhibits at least one characteristic of chronic neuroinflammation.