Non-Volatile Memory Switch with Host Isolation

In a system with multiple host computers and one or more single-port non-volatile memory devices, a non-volatile memory switch receives memory transaction messages from different root complexes corresponding to the multiple host computers. Each of at least some of the memory transaction messages includes a host identifier that identifies a root complex from which the memory transaction was received. The non-volatile memory switch generates modified memory transaction messages at least by changing host identifiers within memory transaction messages to a common value indicative of a single root complex to present to the one or more single-port non-volatile memory devices the different root complexes as the single root complex. The non-volatile memory switch maintains associations of memory transaction messages with corresponding ones of the different root complexes, and sends the modified memory transaction messages to the one or more single-port non-volatile memory devices.