INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF

INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF

The present disclosure is directed to compounds that are inhibitors of HIF-2α having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.

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Bibliographische Detailangaben
Hauptverfasser: LELETI, Manmohan Reddy, DREW, Samuel Lawrie, EPPLIN, Matthew, PODUNAVAC, Masa, MATA, Guillaume, ROSEN, Brandon Reid, HARDMAN, Clayton, FOURNIER, Jeremy, LIU, Dongdong, LAWSON, Kenneth Victor, YU, Kai, POWERS, Jay Patrick, BEATTY, Joel Worley, GAL, Balint, MAILYAN, Artur Karenovich
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure is directed to compounds that are inhibitors of HIF-2α having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.