PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS

PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS

N-(3-Substituted thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides and N-(3-substituted oxazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamidesare disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss.

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Bibliographische Detailangaben
Hauptverfasser: KASTAN, Nathaniel, BAXT, Leigh Ashley, LIANG, Rui, GNEDEVA, Ksenia, MYERS, Robert Walter, HUDSPETH, A. James, HUGGINS, David John, LIVERTON, Nigel John, MEINKE, Peter T, GINN, John David
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:N-(3-Substituted thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides and N-(3-substituted oxazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamidesare disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss.