CD3-FUSION PROTEIN AND USES THEREOF

CD3-FUSION PROTEIN AND USES THEREOF

The present invention provides tools and methods for the TCR independent activation of T-cells, in particular TCR negative T-cells. In particular, the invention relates to CD3-fusion protein comprising a CDS heterodimer comprising a transmembrane domain, and a CD3 domain. The invention further relat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SAILER, Nadja, ELLINGER, Christian
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides tools and methods for the TCR independent activation of T-cells, in particular TCR negative T-cells. In particular, the invention relates to CD3-fusion protein comprising a CDS heterodimer comprising a transmembrane domain, and a CD3 domain. The invention further relates to a nucleic acid molecule encoding such a CD3-fusion protein, a T cell encoding such a CD3-fusion protein as well as said T cell for medical use. Further, the use of the T cell for testing and characterization of exogenous effector molecules is described.