SMALL MOLECULE MODULATORS OF THE BTB DOMAIN OF KEAP1
The present application relates to compounds of formula (I′) or formula (I), such as formula (Ia), and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson...
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creator | Bartholomeus, Johan Bürli, Roland Ostenfeld, Thor Travagli, Massimiliano Jarvis, Rebecca Johnstone, Shawn Terstiege, Ina Turcotte, Stephane |
description | The present application relates to compounds of formula (I′) or formula (I), such as formula (Ia), and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington disease (HD) and other CAG-triplet repeat (or polyglutamine) diseases, amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease), diffuse Lewy body disease, chorea-acanthocytosis, primary lateral sclerosis, multiple sclerosis (MS), frontotemporal dementia, Friedreich's ataxia, acute head injury, and epilepsy (repression of microglia activation). |
format | Patent |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
title | SMALL MOLECULE MODULATORS OF THE BTB DOMAIN OF KEAP1 |
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