SMALL MOLECULE MODULATORS OF THE BTB DOMAIN OF KEAP1

SMALL MOLECULE MODULATORS OF THE BTB DOMAIN OF KEAP1

The present application relates to compounds of formula (I′) or formula (I), such as formula (Ia), and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson&#...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bartholomeus, Johan, Bürli, Roland, Ostenfeld, Thor, Travagli, Massimiliano, Jarvis, Rebecca, Johnstone, Shawn, Terstiege, Ina, Turcotte, Stephane
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present application relates to compounds of formula (I′) or formula (I), such as formula (Ia), and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington disease (HD) and other CAG-triplet repeat (or polyglutamine) diseases, amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease), diffuse Lewy body disease, chorea-acanthocytosis, primary lateral sclerosis, multiple sclerosis (MS), frontotemporal dementia, Friedreich's ataxia, acute head injury, and epilepsy (repression of microglia activation).