GDF15 FUSION PROTEINS AND USES THEREOF

GDF15 FUSION PROTEINS AND USES THEREOF

Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preve...

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Bibliographische Detailangaben
Hauptverfasser: ARMSTRONG, Anthony, HUANG, Chichi, NELSON, Serena, MULLICAN, Shannon, RANGWALA, Shamina M, HUNTER, Michael J, LIN-SCHMIDT, Xiefan, CHAVEZ, Jose Antonio, CONNOR, Judith Ann, FURMAN, Jennifer
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.