N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS

The present invention relates to a class of N-cyanopyrrolidines with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis.

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Bibliographische Detailangaben
Hauptverfasser: THOMPSON, Paul William, KEMP, Mark Ian, LUCKHURST, Christopher Andrew
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to a class of N-cyanopyrrolidines with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis.