VIA CYCLOADDITION BILATERALLY FUNCTIONALIZED ANTIBODIES

The present invention provides antibody-payload conjugates having a payload-to-antibody ratio of 1. The antibody-payload conjugate is according to structure (1):wherein:a, b, c and d are each independently 0 or 1;e is an integer in the range of 0-10;L1, L2 and L3 are linkers;D is a payload;BM is a b...

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Bibliographische Detailangaben
Hauptverfasser:	WIJDEVEN, Maria Antonia, VAN DELFT, Floris Louis, POPAL, Sorraya, HOOGENBOOM, Jorin, VAN SCHAIK, Arnoldus Jacobus, VAN BERKEL, Sander Sebastiaan, VAN GEEL, Remon, DE BEVER, Laureen
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides antibody-payload conjugates having a payload-to-antibody ratio of 1. The antibody-payload conjugate is according to structure (1):wherein:a, b, c and d are each independently 0 or 1;e is an integer in the range of 0-10;L1, L2 and L3 are linkers;D is a payload;BM is a branching moiety;Su is a monosaccharide;G is a monosaccharide moiety;GlcNAc is an N-acetylglucosamine moiety;Fuc is a fucose moiety;Z are connecting groups.The invention further provides a method for preparing the antibody-payload conjugate according to the invention, an intermediate compound in that preparation method, and medical uses of the antibody-payload conjugate according to the invention.