[6R]-MTHF IN 5-FU BASED CHEMOTHERAPY OF BRAF- OR KRAS-MUTATED COLORECTAL CANCER

The present invention relates to the treatment of colorectal cancer in human populations having a high frequency of BRAF- or KRAS-mutations, which involves administering multiple boluses of [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF) in connection with 5-fluorouracil (5-FU) based chemotherapy.

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Bibliographische Detailangaben
Hauptverfasser:	Skintemo, Lisa Katarina, Tell, Roger Ingvar, Lindberg, Per Lennart, Holmén, Per Emil Jonathan
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to the treatment of colorectal cancer in human populations having a high frequency of BRAF- or KRAS-mutations, which involves administering multiple boluses of [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF) in connection with 5-fluorouracil (5-FU) based chemotherapy.