FUSED RING HETEROARYL COMPOUNDS AND USE THEREOF

FUSED RING HETEROARYL COMPOUNDS AND USE THEREOF

The invention provides novel substituted heterocyclic compounds represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of ALK5 and are usef...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEE, Jungwoo, KIM, Sunjoo, YOON, Cheolhwan, KIM, Namhee, SEO, Jeongbeob, HAN, Cheolkyu, LEE, Jinwoo, KANG, Hongjun, YANG, Inho, KANG, Byungnam, SHIN, Youngdo
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention provides novel substituted heterocyclic compounds represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of ALK5 and are useful in the treatment of chronic fibrosis, vascular disorder, obesity, diabetes, autoimmune diseases and cancer.