PROCESSES FOR PREPARING TUCATINIB POLYMORPHS

PROCESSES FOR PREPARING TUCATINIB POLYMORPHS

The present invention is directed to processes for making various polymorphs of tucatinib, designated herein as Form I, Form II, and Form III of tucatinib. These forms can then be used to prepare pharmaceutical formations containing tucatinib. Tucatinib is a tyrosine kinase inhibitor that is indicat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WRIGHT, Mark Alexander, BONNAUD, Thierry, PATTERSON, Adam Ross, PRENTICE, Zoe
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention is directed to processes for making various polymorphs of tucatinib, designated herein as Form I, Form II, and Form III of tucatinib. These forms can then be used to prepare pharmaceutical formations containing tucatinib. Tucatinib is a tyrosine kinase inhibitor that is indicated for the treatment of breast cancer.