Real time performance tuning of network devices

A network device (ND) includes packet processing circuitry and performance optimization circuitry. The packet processing circuitry is connected to a network and is configured to process communication packets for communicating over the network. The packet processing circuitry includes a plurality of configuration registers for setting one or more operation parameters of the ND. The performance optimization circuitry is configured to improve a performance measure of the ND by iteratively calculating the performance measure and adjusting values of one or more of the configuration registers based on the performance measure.