Method and Apparatus to Generate Hyperspectral Image Data with a Medical Imaging Device

Improved fluorescent imaging and other sensor data imaging processes, including hyperspectral imaging, devices, and systems are provided to enhance endoscopes with multiple wavelength capabilities and providing sequential imaging and display. A first optical device is provided for endoscopy imaging in a white light and a fluoresced light mode with an imaging unit including one or more image sensors. A mechanism in the first optical device to automatically adjust the focus of the first optical device using one or more deformable, variable-focus lenses, wherein the automatic focus adjustment compensates for a chromatic focal difference between the light collected at distinct wavelength bands caused by the dispersive or diffractive properties of the optical materials or optical design employed in the construction of the first or second optical devices, or both. Further variable spectrum imaging is enhanced with the use of adjustable spectral filters.